Tag Archives: drug recalls

This Product Has Been Recalled 75 Times

On May 6, 2019, Vivimed Life Sciences put out another recall for losartan.

The American Health Packaging recall of valsartan on March 7, 2019, the 75th recall of blood pressure medication since the initial contamination occurred.

The problem with the contamination of blood pressure medication has gotten so widespread that the FDA authorized a new generic of valsartan to help relieve shortages when lots after lots of the existing medication were recalled.

Also, the agency compiled a list of 40 blood pressure medications that seem free of contamination. You can find that list here.

Which blood pressure drugs have been recalled?

The common prescription drugs for blood pressure that have been recalled so far include valsartan, losartan, and irbesartan in different combinations and from different manufacturers.

Why have the drugs been recalled?

In each case, a recalled drug was contaminated with N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA) or N-Nitroso N-Methyl 4-amino butyric acid (NMBA).

Those chemicals are believed to cause cancer in humans. Research also suggests NDEA can cause liver and blood cell damage.

NDEA is a byproduct of industrial processes, and the FDA is working on identifying how it has been getting into the medication. It can also be created by other chemical reactions. It is found in very low levels in some food and in drinking water, and is used to make rocket fuel.

Can you get cancer from the contaminated drugs?

The FDA says the risk is very low. They estimate that if 8,000 people took the highest valsartan dose, which is 320 milligrams, from recalled batches every day for 4 years, there would likely only be one additional case of cancer over the life of those 8,000 people.

What should you do if you have a perscription for one of the recalled drugs?

Don’t stop taking the medication. The threat from the contamination in the drug is a lesser threat than the consequences of stopping the use of the medication.

However, do contact your pharmacist or Doctor as soon as possible.

They can help you find an alternative.

Because so much of the blood pressure drugs have been recalled, this may be a little more difficult than usual. Also, keep in mind that drugs that are not on the list of recalls are more in demand and therefore the price may have gotten higher.

WebMD has an article up that summarizes the rash of blood pressure medication recalls. You can read the full report here.

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ANOTHER Recall?? More Blood Pressure Meds Taken Off The Market.

“Legacy Pharmaceutical Packaging, LLC Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP, 25mg, 50mg, And 100mg Due to The Detection of Trace Amounts Of N-Nitroso N-Methyl 4-Amino Butyric Acid (NMBA) Impurity Found in The Active Pharmaceutical Ingredient (API)”.

We have been following recall notices about blood pressure drugs valsartan and losartan. 

This latest recall follows several others announced since July, when the FDA announced the recall of five separate valsartan blood pressure drugs over possible NDEA and NDMA contamination.

Many more were announced in August as the recall spread to Canada and the European Union. And earlier this month, a blood pressure drug known as irbesartan was recalled as well.

So far, recall notices have been issued for multiple lots, with multiple updates, by multiple generic drug manufacturers. Some of the manufacturers who issued recalls in the past several months include:

Teva, Legacy, Torrent, Sandov, Macleods,  Aurobindo Pharma USA,   Mylan’s.

This is by far the longest-running, ongoing spread of recalls we’ve noticed in the past three years.

What is going on?

Turns out that we weren’t the only curious ones. Bloomberg.com spent a year investigating the FDA’s regulations of the generic drug industry and found a drop-off in inspections and the softening of penalties when problems are identified. Data integrity is compromised as well. FDA inspections at factories from West Virginia to China give cause to doubt the data meant to prove the safety and efficacy of drugs.

Bloomberg’s has done a lot of research on generic drugs and the FDA’s quality control. One of their conclusion was that due to the data integrity problems, even the drugs that are not being recalled may not be as effective or safe as they are meant to be.

Safety and efficacy concerns are not limited to drugs using active ingredients from India and China, but also to drugs manufactured in the States.

Bloomberg has a host of articles around the subject of generic drugs and where we are headed, and they are not encouraging.

One of the reasons for the increased laxity in regulations may be the generic drug initiative run by Scott Gottlieb, FDA Commissioner.

Scott Gottlieb was the FDA Commissioner since May 2017, and spearheaded several important initiatives. Among these are finding solutions to the opioid crises, food safety modernization, an initiative to minimize youth nicotine, youth vaping, and general nicotine addiction.

Another top priority for Gottlieb was getting more generic drugs into the market. The extra competition would drive down prices. This has drawn praise from both parties in Congress and, as an aside, is one of the issues President Trump said he would take care of if he was voted President. Everybody was happy.

In the effort to fast-track generic drug manufacture, some approvals for generic drugs may have come at the expense of quality assurance and oversight to ensure the efficacy and safety of the drugs.

On March 5, 2019, FDA Commissioner Scott Gottlieb announced that he was resigning from his post as FDA Commissioner. He will be leaving in April. Will the FDA tighten regulations after he leaves? We can’t be sure.

They will definitely keep working on keeping more drugs accessible to more people- and on the other initiatives Gottlieb spearheaded during his reign as the FDA Commissioner.

Perhaps, now that Gottlieb put a system in place, they will spend more time fixing the bugs in the system and plugging the holes that allow ineffective and unsafe drugs to hit the market. Maybe we will all notice that our medication is working better all of a sudden, and spend less time visiting Doctors to try different versions of what is supposed to be the same basic drug. Maybe the drug prices will go up again. Who knows?

In the meantime, keep checking for updates on drug recalls on our website, or go directly to the FDA’s website.

Above all, Be Safe.

______________

We are MedWaste Management – California’s medical waste disposal experts!

Established in 2008, MedWaste Management brings great benefit to the healthcare industry and the general public alike. We publish this blog to to spread useful and practical information to help people stay safe, smart and healthy!

Call us with any questions or to start service at (866) 254-5105. We are always happy to speak!

Check out our services and other great resources in the links below.

Medical Waste Disposal Services 

MedWaste’s Blog Index

Medical Waste Regulations

MedWaste’s Product Store 

Home Generated Medical Waste Drop-Off Points In California